Please join us on April 17 to welcome Eleanna Melcher, an MD/PhD Trainee in the Medical Scientist Training Program (MSTP), to present her work,
About the Research: Proximity to coal-fired power plants (CPP) has been linked to increased mortality and poorer health, but little is known about its effects on Alzheimer’s Disease and Related Dementias (ADRD) or how critical windows of exposures across the life-course may influence ADRD pathogenesis. Air pollution is a modifiable environmental exposure linked to the pathogenesis of ADRD; however, the fundamental mechanisms linking air pollution to ADRD across the life-course are only partially known, motivating the investigation of the environmental-biological relationship to inform novel therapeutic approaches and policy-based strategies for prevention. In order to reduce ADRD disparities through pollution exposure modification and the development of long-term therapies, we need to characterize environmental exposures across the life-course. This work will quantify and describe the nature of life-course exposure to coal-fired power plants’ heavy metal pollution on ADRD neuropathological outcomes, thereby addressing a critical gap in the field of life-course toxin-brain health associations.
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